https://journals.ipsintelligentsia.com/toxicology/index.php/ijt <p><strong>Journal Summary: </strong><strong>Scope:</strong> Publishes in all areas of Toxicology. <strong>ISSN:</strong> Print and Online. <strong>DOI Prefix: </strong>Crossref. <strong>Frequency:</strong> Bimonthly (6 Issues per year). Jan, Mar, May, Jul, Sept, Nov. <strong>Journal model:</strong> Open Access. <strong>Article Processing Charges:</strong> $20 or #15,000. <strong>Abstracting &amp; Indexing:</strong> Google Scholar, Semantic Scholar, Index Copernicus, Crossref, WorldCat. <strong>Type of articles:</strong> All kinds of articles including book of abstracts and conference proceedings. <strong>Review type:</strong> Double-blind peer review. <strong>License type:</strong> CC BY 4.0. <strong>Area of coverage:</strong> Food toxicology, Environmental Toxicology, reproductive toxicology, Forensic Toxicology, Occupational Toxicology, Marine Toxicology, Nanotoxicology, Pharmaceutical Toxicology, Soil and Water Toxicology.</p> en-US editor@ipsintelligentsia.com (Managing Editor) editor@ipsintelligentsia.com (Managing Editor) Mon, 15 Apr 2024 12:41:50 -0600 OJS 3.3.0.7 http://blogs.law.harvard.edu/tech/rss 60 https://journals.ipsintelligentsia.com/toxicology/index.php/ijt/article/view/2 <table> <tbody> <tr> <td> <p>Petroleum products pollution is one of the main cause of environmental toxicity. The study presents the effects of petroleum fractions intoxications with the underlying aim of quantifying the enzymatic activity, level of lipid peroxidation, histopathology and haematological changes in rats. Briefly, twenty-five (25) male rats weighing between 148- 172 g were divided into five groups of five animals each. Group 1, served as the control, Group 2 (rats exposed to cooking gas), Group 3 (exposed to petrol fraction), Group 4 (exposed to kerosene) and Group 5 (exposed to diesel fraction). Oxidative stress biomarkers, superoxide dismutase (SOD) and catalase (CAT) activities, malondialdehyde (MDA) and haematological parameters were quantified in the serum. Histological examination of the lungs was conducted to assess the impact of the inhalation. There was significant (p &lt; 0.05) decrease in SOD activities (Grp1:105.20 ± 1.23, Grp2: 93.04 ± 0.92, Grp3: 88.60 ± 0.74, Grp4: 74.13 ± 0.59 and Grp5: 68.02 ± 0.25 µm/mins/mL) and CAT activities (Grp1: 5.70 ± 0.12, Grp2: 4.3 ± 0.12, Grp3: 3.60 ± 0.32, Grp4: 3.40 ± 0.04, and Grp5: 2.50 ± 0.02 µm/mins/mL) and concomitant rise in MDA levels MDA&nbsp;&nbsp;&nbsp; (Grp1: 88.50 ± 0.32, Grp2: 102.60 ± 0.42, Grp3: 121.30 ± 0.61, Grp4: 130.60 ± 0.72 and Grp5: 140.50 ± 0.95 moles of MDA/g tissues ×10^-5). There was subsequent alteration in lung morphology of the lungs and haematological indices in serum. The findings imply that exposure to petroleum fractions by inhalation is a risk factor in the pathophysiology of pulmonary dysfunction and indication of oxidative stress.</p> </td> </tr> </tbody> </table> Mohammed Salisu Suleiman, Gideon Ayeni, Bashir Alabi Ali, Joseph Eniola Olajide, Francis Onakpa Atanu, Fatima Ajuma Sule, Lukeman Senusi Mohammed, Oluwaseye Ozovehe Yayah, Duniya Sheneni Victor Copyright (c) 2024 IPS Journal of Toxicology https://journals.ipsintelligentsia.com/toxicology/index.php/ijt/article/view/2 Mon, 15 Apr 2024 00:00:00 -0600